Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PDD	tier2	4.30e-01	9.22e-02	1.68e-01	7.66e-02
tier2	PDD	5.66e-01	3.98e-01	2.46e-02	8.74e-02



Evaluating how well PDD genes are linked to tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD	tier2	0.61	0.40	0.64	0.51	2.46
tier2	PDD	0.58	1.59	1.45	1.20	2.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD	tier2	0.00	0.79	2.17	1.10	1.59
tier2	PDD	0.00	0.82	0.49	0.36	0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PDD	53	53	
tier2	46	43	TNSF13;TNSF12;IGH