Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
VD Exclusive	CAD_GS	9.58e-01	9.69e-01	8.96e-01	8.67e-04
CAD_GS Exclusive	VD	5.16e-01	4.27e-01	1.39e-01	2.08e-01
VD Exclusive	CAD_GS Exclusive	9.17e-01	8.98e-01	7.99e-01	1.30e-03
CAD_GS Exclusive	VD Exclusive	4.35e-01	5.15e-01	1.45e-01	2.49e-01
VD Exclusive	Overlap	6.10e-01	6.10e-01	4.31e-01	6.21e-02
CAD_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.09e-03	3.23e-07	6.31e-33	1.93e-12



Evaluating how well VD genes are linked to CAD_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_GS	0.62	0.08	-0.09	0.23	3.53
CAD_GS Exclusive	VD	0.56	0.97	1.32	1.35	1.65
VD Exclusive	CAD_GS Exclusive	0.62	0.05	-0.28	0.39	3.66
CAD_GS Exclusive	VD Exclusive	0.54	0.56	1.01	1.15	1.35
VD Exclusive	Overlap	0.85	0.92	1.29	1.10	1.63
CAD_GS Exclusive	Overlap	1.00	2.72	2.05	1.98	2.47
Overlap	Exclusives	0.69	6.17	6.85	3.63	8.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_GS	0.01	-0.17	-0.35	-0.04	0.77
CAD_GS Exclusive	VD	0.01	8.86	2.24	8.24	1.81
VD Exclusive	CAD_GS Exclusive	0.01	-0.17	-0.47	0.14	0.98
CAD_GS Exclusive	VD Exclusive	0.00	-0.19	-0.15	0.33	0.14
VD Exclusive	Overlap	0.00	-0.18	1.11	-0.01	0.60
CAD_GS Exclusive	Overlap	0.13	114.73	271.28	57.57	431.73
Overlap	Exclusives	0.03	22.48	30.16	14.17	36.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
VD Exclusive	73	72	AL031777.3
CAD_GS Exclusive	76	76	
Overlap	2	2