Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
VD Exclusive	CAD_Cauchy	1.79e-01	1.66e-01	4.62e-01	1.34e-04
CAD_Cauchy Exclusive	VD	2.28e-01	8.48e-01	2.10e-03	7.09e-01
VD Exclusive	CAD_Cauchy Exclusive	2.00e-01	1.74e-01	5.88e-01	2.96e-05
CAD_Cauchy Exclusive	VD Exclusive	2.49e-01	8.32e-01	2.79e-03	7.93e-01
VD Exclusive	Overlap	3.56e-01	1.98e-02	2.18e-01	7.92e-02
CAD_Cauchy Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.19e-02	7.57e-03	3.28e-56	2.07e-10



Evaluating how well VD genes are linked to CAD_Cauchy genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_Cauchy	0.61	-1.01	-1.25	-0.38	4.33
CAD_Cauchy Exclusive	VD	0.53	-0.64	-0.14	0.62	0.91
VD Exclusive	CAD_Cauchy Exclusive	0.61	-1.00	-1.20	-0.30	4.90
CAD_Cauchy Exclusive	VD Exclusive	0.52	-0.53	-0.01	0.40	0.50
VD Exclusive	Overlap	0.97	0.91	inf	1.03	1.66
CAD_Cauchy Exclusive	Overlap	1.00	1.31	1407374883552.00	1.31	1.82
Overlap	Exclusives	0.64	17474014343393.00	4.13	1.89	7.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_Cauchy	0.01	0.27	0.07	0.77	3.44
CAD_Cauchy Exclusive	VD	0.00	0.62	-0.50	1.13	0.24
VD Exclusive	CAD_Cauchy Exclusive	0.01	0.16	0.17	0.73	5.92
CAD_Cauchy Exclusive	VD Exclusive	0.00	-0.24	-0.45	0.23	-0.03
VD Exclusive	Overlap	0.00	0.41	26975148660681420.00	0.67	2.73
CAD_Cauchy Exclusive	Overlap	0.01	7.17	343676919099814.00	9.45	24.63
Overlap	Exclusives	0.02	308210130612862.00	7.38	3.07	13.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
VD Exclusive	74	73	AL031777.3
CAD_Cauchy Exclusive	143	143	
Overlap	1	1