Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
VD Exclusive	CAD_GS	1.00e+00	9.44e-01	7.95e-01	2.49e-04
CAD_GS Exclusive	VD	6.42e-01	4.99e-01	7.12e-02	2.25e-01
VD Exclusive	CAD_GS Exclusive	9.36e-01	7.89e-01	7.43e-01	9.79e-04
CAD_GS Exclusive	VD Exclusive	3.98e-01	4.30e-01	1.27e-01	2.29e-01
VD Exclusive	Overlap	7.92e-01	6.77e-01	4.88e-01	7.30e-02
CAD_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	7.97e-04	6.45e-07	6.29e-31	8.64e-12



Evaluating how well VD genes are linked to CAD_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_GS	0.62	0.22	0.06	0.42	3.99
CAD_GS Exclusive	VD	0.56	1.03	1.12	1.74	1.55
VD Exclusive	CAD_GS Exclusive	0.62	-0.02	-0.56	0.38	3.83
CAD_GS Exclusive	VD Exclusive	0.54	0.59	1.24	1.37	1.57
VD Exclusive	Overlap	0.85	0.83	1.31	0.93	1.72
CAD_GS Exclusive	Overlap	1.00	2.99	1.87	1.75	2.63
Overlap	Exclusives	0.69	6.57	6.37	3.35	8.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_GS	0.01	0.05	-0.26	0.15	1.85
CAD_GS Exclusive	VD	0.01	7.65	6.34	7.01	6.41
VD Exclusive	CAD_GS Exclusive	0.01	-0.12	-0.72	0.15	2.43
CAD_GS Exclusive	VD Exclusive	0.00	-0.20	-0.01	0.46	0.36
VD Exclusive	Overlap	0.00	-0.22	0.94	-0.17	0.44
CAD_GS Exclusive	Overlap	0.13	130.09	204.08	96.97	298.99
Overlap	Exclusives	0.03	24.82	27.47	14.79	16.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
VD Exclusive	73	72	AL031777.3
CAD_GS Exclusive	76	76	
Overlap	2	2