Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
VD Exclusive	CAD_Cauchy	2.68e-01	1.91e-01	6.13e-01	3.89e-05
CAD_Cauchy Exclusive	VD	2.88e-01	8.04e-01	2.37e-03	8.39e-01
VD Exclusive	CAD_Cauchy Exclusive	2.10e-01	2.27e-01	5.82e-01	1.00e-04
CAD_Cauchy Exclusive	VD Exclusive	2.58e-01	8.95e-01	4.12e-03	7.35e-01
VD Exclusive	Overlap	4.55e-01	1.98e-02	2.97e-01	1.98e-02
CAD_Cauchy Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.19e-02	9.52e-03	3.04e-65	6.40e-11



Evaluating how well VD genes are linked to CAD_Cauchy genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_Cauchy	0.61	-0.77	-1.42	-0.51	5.00
CAD_Cauchy Exclusive	VD	0.53	-0.42	-0.13	0.60	0.67
VD Exclusive	CAD_Cauchy Exclusive	0.61	-1.10	-1.07	-0.45	4.36
CAD_Cauchy Exclusive	VD Exclusive	0.52	-0.60	-0.05	0.32	0.64
VD Exclusive	Overlap	0.97	0.79	inf	0.98	1.82
CAD_Cauchy Exclusive	Overlap	1.00	1.19	1407374883552.00	1.00	1.81
Overlap	Exclusives	0.64	17474014343393.00	4.08	2.11	7.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD Exclusive	CAD_Cauchy	0.01	0.40	0.05	0.64	6.99
CAD_Cauchy Exclusive	VD	0.00	0.66	-0.61	1.17	0.19
VD Exclusive	CAD_Cauchy Exclusive	0.01	0.19	0.10	0.48	2.80
CAD_Cauchy Exclusive	VD Exclusive	0.00	-0.16	-0.40	0.29	-0.07
VD Exclusive	Overlap	0.00	0.47	26975148660681420.00	0.89	9.66
CAD_Cauchy Exclusive	Overlap	0.01	9.79	343676919099814.00	20.39	35.52
Overlap	Exclusives	0.02	308210130612862.00	6.98	3.43	10.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
VD Exclusive	74	73	AL031777.3
CAD_Cauchy Exclusive	143	143	
Overlap	1	1