Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
VD	T2D	7.79e-01	5.17e-01	6.77e-01	3.95e-01
T2D	VD	5.67e-01	9.75e-01	5.46e-08	8.74e-01



Evaluating how well VD genes are linked to T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD	T2D	0.75	-0.30	0.07	0.30	1.34
T2D	VD	0.53	0.27	0.04	0.27	0.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD	T2D	0.00	-0.20	0.50	0.10	-0.02
T2D	VD	0.00	0.09	-0.30	-0.10	-0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
VD	75	74	AL031777.3
T2D	11	2	 HNF4A; WFS1; PPARG; KCNJ11; HNF1A; PAX4; AKT2; SLC30A8; GLP1R