Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD98 Exclusive	GStier1	1.63e-06	4.94e-09	5.65e-10	3.42e-10
GStier1 Exclusive	AD98	3.42e-01	3.85e-01	1.89e-01	5.84e-02
AD98 Exclusive	GStier1 Exclusive	3.09e-05	7.47e-08	7.63e-09	6.74e-08
GStier1 Exclusive	AD98 Exclusive	9.31e-01	5.89e-01	2.85e-01	7.93e-02
AD98 Exclusive	Overlap	2.35e-03	1.49e-02	5.36e-04	5.75e-05
GStier1 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-09
Overlap	Exclusives	5.25e-05	1.74e-04	5.36e-14	5.19e-06



Evaluating how well AD98 genes are linked to GStier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD98 Exclusive	GStier1	0.82	3.40	6.08	3.18	6.40
GStier1 Exclusive	AD98	0.58	2.58	1.64	2.29	2.30
AD98 Exclusive	GStier1 Exclusive	0.79	2.95	5.15	3.66	5.01
GStier1 Exclusive	AD98 Exclusive	0.56	2.36	1.03	1.61	2.15
AD98 Exclusive	Overlap	0.97	2.62	2.93	2.76	3.12
GStier1 Exclusive	Overlap	1.00	2.99	2.95	2.93	3.96
Overlap	Exclusives	0.63	3.96	5.04	3.69	6.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD98 Exclusive	GStier1	0.01	10.70	16.51	8.76	22.27
GStier1 Exclusive	AD98	0.03	28.76	31.31	15.09	34.49
AD98 Exclusive	GStier1 Exclusive	0.01	8.42	11.43	8.14	6.03
GStier1 Exclusive	AD98 Exclusive	0.02	17.51	20.89	18.26	17.37
AD98 Exclusive	Overlap	0.01	5.91	12.82	8.10	21.01
GStier1 Exclusive	Overlap	0.10	295.71	169.10	313.94	205.84
Overlap	Exclusives	0.09	101.10	139.57	104.46	149.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD98 Exclusive	94	93	RFPL2
GStier1 Exclusive	27	26	MS4A
Overlap	4	4