Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
NIGADS_WGS_R4_APOE3_79	tier2_gs	7.95e-01	8.29e-01	7.37e-01	9.72e-02
tier2_gs	NIGADS_WGS_R4_APOE3_79	2.95e-01	6.58e-01	9.73e-02	2.97e-01



Evaluating how well NIGADS_WGS_R4_APOE3_79 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_APOE3_79	tier2_gs	0.59	-0.19	-0.58	-0.17	1.79
tier2_gs	NIGADS_WGS_R4_APOE3_79	0.53	-0.91	-0.91	-0.61	0.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_APOE3_79	tier2_gs	0.00	-0.66	-0.32	-0.43	1.10
tier2_gs	NIGADS_WGS_R4_APOE3_79	0.00	-1.01	-0.39	-0.58	-0.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
NIGADS_WGS_R4_APOE3_79	79	78	AC139530.2
tier2_gs	46	43	TNSF12;IGH;TNSF13