Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
NIGADS_WGS_R4_OLD_69 Exclusive	tier1_31	7.40e-05	4.52e-04	2.40e-05	1.64e-07
tier1_31 Exclusive	NIGADS_WGS_R4_OLD_69	8.82e-02	6.39e-01	4.22e-01	5.43e-02
NIGADS_WGS_R4_OLD_69 Exclusive	tier1_31 Exclusive	3.45e-05	6.47e-04	5.98e-06	1.08e-06
tier1_31 Exclusive	NIGADS_WGS_R4_OLD_69 Exclusive	5.83e-02	6.16e-01	4.46e-01	8.01e-02
NIGADS_WGS_R4_OLD_69 Exclusive	Overlap	1.58e-01	6.34e-01	4.75e-01	5.15e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.39e-04	1.41e-04	3.47e-05	7.56e-05



Evaluating how well NIGADS_WGS_R4_OLD_69 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_OLD_69 Exclusive	tier1_31	0.79	3.26	3.98	2.73	5.83
tier1_31 Exclusive	NIGADS_WGS_R4_OLD_69	0.56	-0.07	0.32	0.41	1.51
NIGADS_WGS_R4_OLD_69 Exclusive	tier1_31 Exclusive	0.79	3.38	4.26	3.23	5.77
tier1_31 Exclusive	NIGADS_WGS_R4_OLD_69 Exclusive	0.55	-0.25	0.29	0.36	1.37
NIGADS_WGS_R4_OLD_69 Exclusive	Overlap	0.73	1.71	0.66	0.77	0.91
tier1_31 Exclusive	Overlap	0.99	2.27	1.64	2.01	1.61
Overlap	Exclusives	0.64	1.66	3.86	1.75	5.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_OLD_69 Exclusive	tier1_31	0.00	4.68	4.59	2.71	6.00
tier1_31 Exclusive	NIGADS_WGS_R4_OLD_69	0.01	1.98	8.15	7.17	7.72
NIGADS_WGS_R4_OLD_69 Exclusive	tier1_31 Exclusive	0.00	4.26	4.86	2.07	4.68
tier1_31 Exclusive	NIGADS_WGS_R4_OLD_69 Exclusive	0.01	3.65	8.08	6.72	6.35
NIGADS_WGS_R4_OLD_69 Exclusive	Overlap	0.00	0.95	0.07	0.05	-0.10
tier1_31 Exclusive	Overlap	0.01	33.64	12.11	17.55	27.78
Overlap	Exclusives	0.01	3.66	7.56	2.20	4.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
NIGADS_WGS_R4_OLD_69 Exclusive	68	67	AC018755.2
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1