Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
NIGADS_WGS_R4_OLD_69 Exclusive	tier2_gs	1.20e-01	1.37e-01	7.97e-02	4.97e-03
tier2_gs Exclusive	NIGADS_WGS_R4_OLD_69	7.56e-01	7.19e-01	9.60e-02	2.95e-01
NIGADS_WGS_R4_OLD_69 Exclusive	tier2_gs Exclusive	1.27e-01	1.24e-01	7.14e-02	3.11e-03
tier2_gs Exclusive	NIGADS_WGS_R4_OLD_69 Exclusive	7.26e-01	7.58e-01	6.46e-02	3.13e-01
NIGADS_WGS_R4_OLD_69 Exclusive	Overlap	7.92e-02	1.98e-02	1.98e-01	5.54e-01
tier2_gs Exclusive	Overlap	1.98e-02	2.18e-01	7.52e-01	9.70e-01
Overlap	Exclusives	1.35e-01	4.08e-01	4.61e-02	5.27e-01



Evaluating how well NIGADS_WGS_R4_OLD_69 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_OLD_69 Exclusive	tier2_gs	0.65	1.87	2.00	1.34	3.15
tier2_gs Exclusive	NIGADS_WGS_R4_OLD_69	0.56	1.19	1.07	0.53	1.64
NIGADS_WGS_R4_OLD_69 Exclusive	tier2_gs Exclusive	0.66	1.88	2.52	1.42	3.29
tier2_gs Exclusive	NIGADS_WGS_R4_OLD_69 Exclusive	0.56	1.33	1.07	0.82	1.84
NIGADS_WGS_R4_OLD_69 Exclusive	Overlap	0.26	-1.57	-2.82	-1.57	-0.81
tier2_gs Exclusive	Overlap	0.48	-2.39	-1.51	-0.84	-0.08
Overlap	Exclusives	0.53	-1.59	-1.66	-1.13	1.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_OLD_69 Exclusive	tier2_gs	0.00	1.89	3.49	2.34	4.82
tier2_gs Exclusive	NIGADS_WGS_R4_OLD_69	0.01	2.70	2.11	1.95	0.97
NIGADS_WGS_R4_OLD_69 Exclusive	tier2_gs Exclusive	0.00	2.20	4.84	2.42	2.58
tier2_gs Exclusive	NIGADS_WGS_R4_OLD_69 Exclusive	0.01	1.79	2.60	2.45	0.86
NIGADS_WGS_R4_OLD_69 Exclusive	Overlap	0.00	-0.23	-0.36	-0.44	-0.29
tier2_gs Exclusive	Overlap	0.00	-0.55	-0.58	-0.31	-0.28
Overlap	Exclusives	0.01	-1.73	-0.84	-0.89	-0.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
NIGADS_WGS_R4_OLD_69 Exclusive	68	67	AC018755.2
tier2_gs Exclusive	45	42	TNSF12;IGH;TNSF13
Overlap	1	1