Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
NIGADS_WGS_R4_YOUNG_120	tier2_gs	5.19e-01	3.13e-01	5.58e-01	9.94e-02
tier2_gs	NIGADS_WGS_R4_YOUNG_120	7.76e-02	4.33e-01	1.11e-04	7.45e-01



Evaluating how well NIGADS_WGS_R4_YOUNG_120 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_YOUNG_120	tier2_gs	0.61	0.27	1.10	0.22	2.18
tier2_gs	NIGADS_WGS_R4_YOUNG_120	0.51	1.54	1.08	1.36	0.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIGADS_WGS_R4_YOUNG_120	tier2_gs	0.00	0.87	2.84	0.91	1.11
tier2_gs	NIGADS_WGS_R4_YOUNG_120	0.01	0.72	0.18	0.18	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
NIGADS_WGS_R4_YOUNG_120	120	117	MUC2;CHURC1-FNTB;REXO5
tier2_gs	46	43	TNSF13;TNSF12;IGH