Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier1_31	8.45e-04	5.04e-04	1.63e-03	6.67e-07
tier1_31 Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87	3.30e-01	4.81e-01	3.55e-01	5.05e-01
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier1_31 Exclusive	2.37e-03	1.92e-04	9.25e-04	4.95e-06
tier1_31 Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	6.05e-01	6.77e-01	5.61e-01	9.52e-01
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	Overlap	8.22e-02	7.71e-02	8.78e-02	5.29e-02
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-06	1.74e-06	8.71e-06
Overlap	Exclusives	1.18e-05	3.11e-07	1.89e-14	7.60e-07



Evaluating how well Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier1_31	0.77	2.47	4.27	2.60	5.37
tier1_31 Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87	0.52	1.37	1.49	1.90	0.53
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier1_31 Exclusive	0.76	2.08	3.83	2.72	4.55
tier1_31 Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	0.50	0.90	1.03	1.29	0.10
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	Overlap	0.90	2.24	2.27	1.95	2.31
tier1_31 Exclusive	Overlap	1.00	3.20	2.60	2.83	2.76
Overlap	Exclusives	0.62	3.79	6.28	3.23	4.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier1_31	0.01	5.74	10.53	5.50	5.09
tier1_31 Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87	0.01	10.57	8.60	10.63	13.54
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier1_31 Exclusive	0.01	2.07	7.94	4.27	7.47
tier1_31 Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	0.01	0.75	3.64	3.90	1.22
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	Overlap	0.00	18.14	23.35	15.14	4.42
tier1_31 Exclusive	Overlap	0.05	63.26	83.12	59.72	12.26
Overlap	Exclusives	0.05	48.42	79.10	28.03	32.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	84	82	TMEM191C;AC093155.3
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3