Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier2_gs	1.79e-01	1.19e-01	1.48e-01	5.47e-03
tier2_gs Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87	3.78e-01	3.49e-01	2.22e-03	3.91e-01
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier2_gs Exclusive	1.44e-01	1.16e-01	1.18e-01	2.10e-03
tier2_gs Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	4.90e-01	2.07e-01	2.99e-03	3.52e-01
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	Overlap	9.50e-01	7.13e-01	9.70e-01	9.90e-02
tier2_gs Exclusive	Overlap	1.39e-01	4.36e-01	1.78e-01	1.58e-01
Overlap	Exclusives	2.42e-02	3.45e-01	2.57e-25	2.21e-01



Evaluating how well Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier2_gs	0.67	1.31	2.76	1.81	3.76
tier2_gs Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87	0.53	2.52	1.89	1.98	0.95
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier2_gs Exclusive	0.69	1.61	2.46	2.41	3.99
tier2_gs Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	0.54	1.85	2.28	1.99	1.15
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	Overlap	0.03	-0.44	-0.63	-0.32	-1.54
tier2_gs Exclusive	Overlap	0.07	-0.02	-0.19	-0.13	-1.58
Overlap	Exclusives	0.54	0.55	0.99	0.59	1.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier2_gs	0.01	3.76	5.79	4.95	1.42
tier2_gs Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87	0.01	3.55	0.95	4.12	3.32
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	tier2_gs Exclusive	0.01	4.80	6.46	6.35	5.89
tier2_gs Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	0.01	5.49	1.38	4.21	1.68
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	Overlap	0.00	-0.19	-0.13	-0.11	-0.15
tier2_gs Exclusive	Overlap	0.00	-0.14	-0.17	-0.13	-0.29
Overlap	Exclusives	0.01	-0.01	0.07	0.04	0.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_stats_related_clean_AD_ADC_HC_selected_2_APOE4_AD_APOE3_HC_87 Exclusive	86	84	TMEM191C;AC093155.3
tier2_gs Exclusive	45	42	TNSF13;IGH;TNSF12
Overlap	1	1