Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
APOE44 AD of ADC HC of OLD excluding APOE34_4_84	tier2_gs	2.93e-01	1.32e-01	1.45e-01	1.06e-02
tier2_gs	APOE44 AD of ADC HC of OLD excluding APOE34_4_84	5.01e-01	2.77e-01	7.73e-03	3.11e-01



Evaluating how well APOE44 AD of ADC HC of OLD excluding APOE34_4_84 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE44 AD of ADC HC of OLD excluding APOE34_4_84	tier2_gs	0.64	0.88	1.32	1.26	3.18
tier2_gs	APOE44 AD of ADC HC of OLD excluding APOE34_4_84	0.55	1.76	1.73	1.62	1.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE44 AD of ADC HC of OLD excluding APOE34_4_84	tier2_gs	0.00	1.66	3.88	2.66	0.54
tier2_gs	APOE44 AD of ADC HC of OLD excluding APOE34_4_84	0.01	1.90	0.50	1.45	0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
APOE44 AD of ADC HC of OLD excluding APOE34_4_84	84	83	TMEM191C
tier2_gs	46	43	IGH;TNSF12;TNSF13