Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_male Exclusive	Juan_SS	4.86e-01	6.88e-01	3.83e-01	4.81e-01
Juan_SS Exclusive	PD_male	6.40e-01	3.88e-01	1.09e-03	3.94e-01
PD_male Exclusive	Juan_SS Exclusive	3.87e-01	6.61e-01	2.56e-01	2.73e-01
Juan_SS Exclusive	PD_male Exclusive	7.20e-01	5.39e-01	2.38e-02	5.78e-01
PD_male Exclusive	Overlap	1.98e-02	9.90e-02	1.98e-02	4.16e-01
Juan_SS Exclusive	Overlap	1.98e-02	1.19e-01	1.98e-02	3.96e-02
Overlap	Exclusives	8.95e-02	4.56e-01	4.47e-07	5.90e-01



Evaluating how well PD_male genes are linked to Juan_SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_male Exclusive	Juan_SS	0.54	-0.60	-0.04	-0.22	0.45
Juan_SS Exclusive	PD_male	0.53	1.17	1.42	1.65	1.47
PD_male Exclusive	Juan_SS Exclusive	0.58	0.10	0.39	0.44	1.05
Juan_SS Exclusive	PD_male Exclusive	0.53	0.99	1.07	1.04	1.03
PD_male Exclusive	Overlap	0.16	-2.35	-1.34	-1.87	-1.13
Juan_SS Exclusive	Overlap	0.99	3.33	1.30	2.03	1.71
Overlap	Exclusives	0.48	-0.86	-1.73	-0.85	-1.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_male Exclusive	Juan_SS	0.00	0.05	0.16	0.43	0.44
Juan_SS Exclusive	PD_male	0.01	1.06	0.43	0.91	0.58
PD_male Exclusive	Juan_SS Exclusive	0.00	0.32	0.38	1.09	0.18
Juan_SS Exclusive	PD_male Exclusive	0.01	0.77	0.23	0.69	0.47
PD_male Exclusive	Overlap	0.00	-0.39	-0.25	-0.39	-0.15
Juan_SS Exclusive	Overlap	0.00	90.62	2.67	10.16	3.19
Overlap	Exclusives	0.01	-0.76	-1.38	-0.88	-0.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_male Exclusive	128	128	
Juan_SS Exclusive	10	10	
Overlap	1	1