Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_male	Jansen	7.01e-01	8.72e-01	7.24e-01	4.06e-01
Jansen	PD_male	8.92e-01	6.10e-01	3.76e-02	7.53e-01



Evaluating how well PD_male genes are linked to Jansen genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_male	Jansen	0.44	-0.54	-0.36	-0.22	-0.96
Jansen	PD_male	0.48	-0.86	-1.17	-0.96	-0.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_male	Jansen	0.00	-0.49	-0.31	-0.30	-0.69
Jansen	PD_male	0.01	-0.43	-0.59	-0.41	-0.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_male	129	129	
Jansen	27	25	ZN27F543;SSPO