Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_male	Singleton	1.79e-01	6.60e-02	8.77e-02	8.24e-05
Singleton	PD_male	4.64e-01	1.64e-01	1.01e-11	7.18e-02



Evaluating how well PD_male genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_male	Singleton	0.78	1.71	2.52	1.55	4.92
Singleton	PD_male	0.56	2.94	2.41	2.70	2.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_male	Singleton	0.00	1.46	2.79	1.66	4.47
Singleton	PD_male	0.01	2.36	0.72	1.95	0.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_male	129	129	
Singleton	21	21