Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_female	Juan_GS	1.90e-01	7.94e-01	1.03e-01	3.78e-03
Juan_GS	PD_female	7.61e-03	2.73e-01	3.95e-12	2.90e-01



Evaluating how well PD_female genes are linked to Juan_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Juan_GS	0.80	1.12	0.73	1.18	3.53
Juan_GS	PD_female	0.53	-0.98	-0.23	-0.40	1.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Juan_GS	0.00	1.95	1.20	3.40	1.76
Juan_GS	PD_female	0.01	0.86	2.14	1.58	1.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_female	92	92	
Juan_GS	12	12