Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_female	Jansen	2.52e-01	4.70e-01	2.19e-01	6.64e-01
Jansen	PD_female	4.74e-01	2.87e-01	3.83e-01	2.94e-02



Evaluating how well PD_female genes are linked to Jansen genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Jansen	0.49	0.77	0.50	0.34	-0.16
Jansen	PD_female	0.56	0.78	1.32	0.96	2.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Jansen	0.00	1.93	0.97	1.75	2.16
Jansen	PD_female	0.01	1.02	1.69	0.98	1.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_female	92	92	
Jansen	27	25	ZN27F543;SSPO