Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_female	Singleton	5.47e-02	4.51e-02	1.22e-02	5.73e-06
Singleton	PD_female	3.45e-01	6.85e-01	1.22e-05	4.49e-01



Evaluating how well PD_female genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Singleton	0.76	1.52	1.72	1.52	4.44
Singleton	PD_female	0.55	0.61	0.41	0.58	1.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Singleton	0.00	1.61	2.37	2.51	0.34
Singleton	PD_female	0.01	0.34	0.95	1.30	1.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_female	92	92	
Singleton	21	21