Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_female	Juan_SS	9.51e-01	5.80e-01	9.70e-01	8.27e-01
Juan_SS	PD_female	6.71e-01	5.40e-01	1.18e-02	3.82e-02



Evaluating how well PD_female genes are linked to Juan_SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Juan_SS	0.53	0.31	-0.66	-0.22	0.37
Juan_SS	PD_female	0.56	0.97	1.15	0.81	2.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Juan_SS	0.00	0.62	-0.13	0.22	-0.11
Juan_SS	PD_female	0.01	0.35	0.52	-0.04	0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_female	92	92	
Juan_SS	11	11