Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_combined	Singleton	3.84e-02	1.12e-02	4.73e-02	4.95e-06
Singleton	PD_combined	2.51e-01	4.34e-01	4.31e-13	4.53e-01



Evaluating how well PD_combined genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined	Singleton	0.82	1.97	3.41	2.47	4.27
Singleton	PD_combined	0.53	2.57	1.58	2.13	1.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined	Singleton	0.01	3.18	6.72	4.38	7.56
Singleton	PD_combined	0.01	6.37	3.29	2.33	2.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_combined	168	167	AP000781.2
Singleton	21	21