Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_combined	GS_Juan	3.23e-02	2.91e-02	7.43e-02	1.18e-03
GS_Juan	PD_combined	4.54e-02	7.32e-01	1.16e-19	7.99e-01



Evaluating how well PD_combined genes are linked to GS_Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined	GS_Juan	0.81	1.08	1.52	0.96	3.77
GS_Juan	PD_combined	0.51	0.41	0.85	1.13	0.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined	GS_Juan	0.00	3.19	4.43	2.32	4.84
GS_Juan	PD_combined	0.01	1.54	1.54	1.87	0.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_combined	168	167	AP000781.2
GS_Juan	12	12