Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_combined Exclusive	Jansen	9.50e-01	7.31e-01	9.82e-01	9.48e-01
Jansen Exclusive	PD_combined	7.45e-01	3.07e-01	5.06e-02	1.57e-01
PD_combined Exclusive	Jansen Exclusive	8.88e-01	7.96e-01	8.85e-01	9.87e-01
Jansen Exclusive	PD_combined Exclusive	5.46e-01	4.25e-01	1.04e-01	2.73e-01
PD_combined Exclusive	Overlap	5.15e-01	5.15e-01	3.96e-01	4.75e-01
Jansen Exclusive	Overlap	3.56e-01	6.73e-01	3.96e-01	5.15e-01
Overlap	Exclusives	7.42e-01	9.38e-01	6.66e-02	9.88e-01



Evaluating how well PD_combined genes are linked to Jansen genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined Exclusive	Jansen	0.49	0.33	0.74	0.35	-0.22
Jansen Exclusive	PD_combined	0.49	-0.26	-0.41	0.07	-0.54
PD_combined Exclusive	Jansen Exclusive	0.50	0.40	0.81	0.57	-0.17
Jansen Exclusive	PD_combined Exclusive	0.49	0.08	-0.38	0.12	-0.42
PD_combined Exclusive	Overlap	0.25	-0.95	-0.84	-1.03	-0.85
Jansen Exclusive	Overlap	0.24	-1.03	-0.76	-0.75	-0.96
Overlap	Exclusives	0.50	-0.20	0.26	0.27	-0.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined Exclusive	Jansen	0.00	-0.14	0.25	-0.12	-0.20
Jansen Exclusive	PD_combined	0.01	0.04	0.30	0.14	-0.15
PD_combined Exclusive	Jansen Exclusive	0.00	0.19	0.15	-0.06	-0.27
Jansen Exclusive	PD_combined Exclusive	0.01	0.27	-0.02	0.30	-0.11
PD_combined Exclusive	Overlap	0.00	-0.24	-0.21	-0.28	-0.37
Jansen Exclusive	Overlap	0.00	-0.25	-0.38	-0.25	-0.35
Overlap	Exclusives	0.01	-0.75	-0.22	-0.31	-0.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_combined Exclusive	167	166	AP000781.2
Jansen Exclusive	26	24	ZN27F543;SSPO
Overlap	1	1