Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_AF_cutoff Exclusive	GS_31	1.11e-06	5.33e-09	2.73e-10	1.34e-10
GS_31 Exclusive	98_AF_cutoff	3.12e-01	3.02e-01	1.75e-01	4.24e-02
98_AF_cutoff Exclusive	GS_31 Exclusive	1.41e-05	1.38e-07	2.69e-08	2.23e-08
GS_31 Exclusive	98_AF_cutoff Exclusive	9.44e-01	3.37e-01	3.71e-01	1.01e-01
98_AF_cutoff Exclusive	Overlap	3.70e-03	1.49e-02	7.22e-04	1.08e-04
GS_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	4.82e-05	2.28e-04	1.49e-12	1.21e-05



Evaluating how well 98_AF_cutoff genes are linked to GS_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_AF_cutoff Exclusive	GS_31	0.82	3.87	6.23	3.66	6.48
GS_31 Exclusive	98_AF_cutoff	0.58	2.48	1.66	2.40	2.40
98_AF_cutoff Exclusive	GS_31 Exclusive	0.79	3.29	5.61	3.26	5.47
GS_31 Exclusive	98_AF_cutoff Exclusive	0.56	2.17	1.24	1.51	2.00
98_AF_cutoff Exclusive	Overlap	0.97	2.33	3.31	2.28	3.17
GS_31 Exclusive	Overlap	1.00	2.55	3.53	2.80	3.60
Overlap	Exclusives	0.63	4.12	5.19	3.62	4.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_AF_cutoff Exclusive	GS_31	0.01	10.60	20.02	14.95	18.77
GS_31 Exclusive	98_AF_cutoff	0.03	28.19	29.46	30.34	25.29
98_AF_cutoff Exclusive	GS_31 Exclusive	0.01	7.78	15.28	10.77	4.96
GS_31 Exclusive	98_AF_cutoff Exclusive	0.02	18.35	20.16	8.78	21.43
98_AF_cutoff Exclusive	Overlap	0.01	8.13	15.66	8.48	5.67
GS_31 Exclusive	Overlap	0.10	242.54	116.25	236.18	15.18
Overlap	Exclusives	0.09	63.83	131.35	105.05	162.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_AF_cutoff Exclusive	94	93	RFPL2
GS_31 Exclusive	27	26	MS4A
Overlap	4	4