Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
APOE3 Age filtered_z3 Exclusive	tier1_31	2.26e-01	8.42e-02	4.85e-02	5.79e-04
tier1_31 Exclusive	APOE3 Age filtered_z3	3.64e-02	7.15e-01	1.81e-01	1.76e-01
APOE3 Age filtered_z3 Exclusive	tier1_31 Exclusive	2.00e-01	1.19e-01	4.53e-02	1.76e-03
tier1_31 Exclusive	APOE3 Age filtered_z3 Exclusive	5.56e-02	9.27e-01	2.20e-01	1.88e-01
APOE3 Age filtered_z3 Exclusive	Overlap	7.92e-01	6.73e-01	5.94e-01	9.31e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.54e-06	1.89e-04	1.41e-06	5.84e-06



Evaluating how well APOE3 Age filtered_z3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE3 Age filtered_z3 Exclusive	tier1_31	0.68	1.52	2.12	1.41	3.57
tier1_31 Exclusive	APOE3 Age filtered_z3	0.54	0.70	0.86	0.98	2.16
APOE3 Age filtered_z3 Exclusive	tier1_31 Exclusive	0.69	1.28	2.34	1.32	3.18
tier1_31 Exclusive	APOE3 Age filtered_z3 Exclusive	0.54	0.59	0.40	0.68	2.00
APOE3 Age filtered_z3 Exclusive	Overlap	0.59	0.17	0.38	0.39	0.18
tier1_31 Exclusive	Overlap	1.00	1.70	1.91	2.19	1.74
Overlap	Exclusives	0.59	2.05	3.29	2.02	5.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE3 Age filtered_z3 Exclusive	tier1_31	0.00	1.09	1.99	0.98	0.25
tier1_31 Exclusive	APOE3 Age filtered_z3	0.01	2.45	2.98	3.26	3.15
APOE3 Age filtered_z3 Exclusive	tier1_31 Exclusive	0.00	0.84	2.13	1.11	3.17
tier1_31 Exclusive	APOE3 Age filtered_z3 Exclusive	0.01	1.68	1.33	1.12	3.11
APOE3 Age filtered_z3 Exclusive	Overlap	0.00	-0.18	-0.20	-0.24	-0.28
tier1_31 Exclusive	Overlap	0.06	82.89	74.56	675.30	114.43
Overlap	Exclusives	0.03	7.83	19.14	9.38	22.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
APOE3 Age filtered_z3 Exclusive	184	182	RFPL2;AC093155.3
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1