Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
APOE3 Age filtered_z35 Exclusive	tier1_31	5.18e-01	2.99e-01	1.82e-01	5.80e-02
tier1_31 Exclusive	APOE3 Age filtered_z35	1.02e-01	8.86e-01	5.50e-01	2.72e-01
APOE3 Age filtered_z35 Exclusive	tier1_31 Exclusive	5.25e-01	1.95e-01	1.82e-01	4.35e-02
tier1_31 Exclusive	APOE3 Age filtered_z35 Exclusive	1.52e-01	8.68e-01	6.81e-01	4.78e-01
APOE3 Age filtered_z35 Exclusive	Overlap	6.73e-01	9.70e-01	8.71e-01	9.11e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.58e-07	3.09e-06	9.19e-08	5.96e-07



Evaluating how well APOE3 Age filtered_z35 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE3 Age filtered_z35 Exclusive	tier1_31	0.59	-0.02	0.22	0.02	1.56
tier1_31 Exclusive	APOE3 Age filtered_z35	0.53	0.25	0.08	0.42	1.43
APOE3 Age filtered_z35 Exclusive	tier1_31 Exclusive	0.60	-0.06	0.29	0.11	1.59
tier1_31 Exclusive	APOE3 Age filtered_z35 Exclusive	0.53	0.10	-0.09	0.11	0.91
APOE3 Age filtered_z35 Exclusive	Overlap	0.54	0.36	-0.15	-0.01	-0.04
tier1_31 Exclusive	Overlap	1.00	1.99	1.78	1.92	1.46
Overlap	Exclusives	0.62	2.57	3.40	2.41	4.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE3 Age filtered_z35 Exclusive	tier1_31	0.00	-0.02	0.81	-0.10	1.28
tier1_31 Exclusive	APOE3 Age filtered_z35	0.01	1.89	0.76	1.69	1.93
APOE3 Age filtered_z35 Exclusive	tier1_31 Exclusive	0.00	-0.04	0.92	0.15	0.86
tier1_31 Exclusive	APOE3 Age filtered_z35 Exclusive	0.01	0.36	-0.20	0.16	0.07
APOE3 Age filtered_z35 Exclusive	Overlap	0.00	-0.20	-0.38	-0.27	-0.22
tier1_31 Exclusive	Overlap	0.06	117.18	102.19	138.25	74.87
Overlap	Exclusives	0.03	12.54	33.38	19.73	22.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
APOE3 Age filtered_z35 Exclusive	105	103	AC093155.3;RFPL2
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1