Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
APOE4 Age filtered_z3 Exclusive	tier1_31	5.89e-01	5.06e-01	5.26e-01	1.10e-01
tier1_31 Exclusive	APOE4 Age filtered_z3	1.59e-01	4.58e-01	8.05e-02	5.25e-02
APOE4 Age filtered_z3 Exclusive	tier1_31 Exclusive	9.56e-01	7.68e-01	7.65e-01	2.15e-01
tier1_31 Exclusive	APOE4 Age filtered_z3 Exclusive	1.20e-01	4.20e-01	1.45e-01	5.07e-02
APOE4 Age filtered_z3 Exclusive	Overlap	1.18e-02	5.17e-01	4.43e-03	9.85e-04
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	9.08e-05	8.12e-05	6.07e-26	2.53e-05



Evaluating how well APOE4 Age filtered_z3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE4 Age filtered_z3 Exclusive	tier1_31	0.62	0.43	0.42	0.18	2.32
tier1_31 Exclusive	APOE4 Age filtered_z3	0.55	1.33	0.74	1.27	1.85
APOE4 Age filtered_z3 Exclusive	tier1_31 Exclusive	0.60	0.19	0.08	0.12	1.81
tier1_31 Exclusive	APOE4 Age filtered_z3 Exclusive	0.54	0.95	0.86	1.19	1.86
APOE4 Age filtered_z3 Exclusive	Overlap	0.99	2.50	1.69	2.00	2.72
tier1_31 Exclusive	Overlap	1.00	2.42	2.20	2.29	2.54
Overlap	Exclusives	0.61	3.17	4.79	2.62	4.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE4 Age filtered_z3 Exclusive	tier1_31	0.00	0.93	0.84	0.47	2.10
tier1_31 Exclusive	APOE4 Age filtered_z3	0.01	2.56	1.62	1.57	2.47
APOE4 Age filtered_z3 Exclusive	tier1_31 Exclusive	0.00	0.27	0.41	0.19	1.55
tier1_31 Exclusive	APOE4 Age filtered_z3 Exclusive	0.01	0.16	0.61	0.28	1.03
APOE4 Age filtered_z3 Exclusive	Overlap	0.00	6.42	2.81	6.34	5.97
tier1_31 Exclusive	Overlap	0.05	177.69	139.65	122.53	61.28
Overlap	Exclusives	0.04	18.61	42.43	27.54	27.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
APOE4 Age filtered_z3 Exclusive	149	148	RFPL2
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2