Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_combined Exclusive	AD_tier1_31	2.05e-01	1.76e-01	3.92e-01	3.67e-03
AD_tier1_31 Exclusive	LBD_combined	1.39e-02	6.48e-01	3.97e-01	7.36e-01
LBD_combined Exclusive	AD_tier1_31 Exclusive	1.79e-01	1.55e-01	3.54e-01	9.06e-03
AD_tier1_31 Exclusive	LBD_combined Exclusive	1.43e-02	6.94e-01	3.51e-01	6.51e-01
LBD_combined Exclusive	Overlap	4.95e-01	1.98e-02	6.34e-01	7.92e-02
AD_tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.28e-05	2.92e-04	2.71e-69	3.85e-05



Evaluating how well LBD_combined genes are linked to AD_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_combined Exclusive	AD_tier1_31	0.66	1.10	1.67	0.57	3.06
AD_tier1_31 Exclusive	LBD_combined	0.50	0.43	0.07	0.10	0.14
LBD_combined Exclusive	AD_tier1_31 Exclusive	0.65	1.09	1.90	0.65	2.50
AD_tier1_31 Exclusive	LBD_combined Exclusive	0.50	0.31	0.10	-0.14	0.00
LBD_combined Exclusive	Overlap	0.98	0.79	128922979459803.00	0.75	1.83
AD_tier1_31 Exclusive	Overlap	1.00	1.19	inf	1.70	1.98
Overlap	Exclusives	0.58	144059224205907.00	4.99	2.80	4.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_combined Exclusive	AD_tier1_31	0.00	0.29	0.69	-0.12	1.14
AD_tier1_31 Exclusive	LBD_combined	0.01	0.96	0.28	0.63	0.43
LBD_combined Exclusive	AD_tier1_31 Exclusive	0.00	0.42	0.83	-0.03	0.47
AD_tier1_31 Exclusive	LBD_combined Exclusive	0.01	0.17	0.14	-0.07	-0.12
LBD_combined Exclusive	Overlap	0.00	0.16	4051876407858447.00	0.20	2.21
AD_tier1_31 Exclusive	Overlap	0.02	24.70	151272923003761312.00	68.60	27.14
Overlap	Exclusives	0.02	1350442052848551.75	8.58	5.76	9.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_combined Exclusive	200	200	
AD_tier1_31 Exclusive	30	29	MS4A
Overlap	1	1