Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_male Exclusive	AD_tier1_31	6.06e-04	9.80e-04	6.32e-05	2.35e-05
AD_tier1_31 Exclusive	LBD_male	6.32e-02	2.19e-03	3.95e-03	6.68e-05
LBD_male Exclusive	AD_tier1_31 Exclusive	6.99e-04	4.81e-04	9.63e-06	2.76e-05
AD_tier1_31 Exclusive	LBD_male Exclusive	7.03e-02	1.68e-03	5.40e-03	4.32e-05
LBD_male Exclusive	Overlap	5.54e-01	1.98e-02	7.92e-02	7.92e-02
AD_tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	1.50e-04	9.75e-05	1.21e-48	2.69e-10



Evaluating how well LBD_male genes are linked to AD_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male Exclusive	AD_tier1_31	0.73	2.38	3.42	1.76	3.96
AD_tier1_31 Exclusive	LBD_male	0.63	3.46	3.63	3.05	4.54
LBD_male Exclusive	AD_tier1_31 Exclusive	0.72	2.01	3.44	2.44	4.52
AD_tier1_31 Exclusive	LBD_male Exclusive	0.62	3.59	3.38	2.81	5.24
LBD_male Exclusive	Overlap	0.98	0.55	-124137081470062.00	1.07	1.73
AD_tier1_31 Exclusive	Overlap	1.00	1.07	inf	1.45	1.82
Overlap	Exclusives	0.67	377916128426896.00	6.46	2.50	6.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male Exclusive	AD_tier1_31	0.01	5.44	7.44	3.13	9.01
AD_tier1_31 Exclusive	LBD_male	0.01	5.34	3.23	6.44	4.05
LBD_male Exclusive	AD_tier1_31 Exclusive	0.01	3.57	11.49	6.11	2.17
AD_tier1_31 Exclusive	LBD_male Exclusive	0.01	5.26	1.64	5.21	7.14
LBD_male Exclusive	Overlap	0.00	-0.18	-inf	2.18	1.90
AD_tier1_31 Exclusive	Overlap	0.02	17.06	151272923003761312.00	57.54	8.81
Overlap	Exclusives	0.02	2326773939787428.00	8.06	4.98	16.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_male Exclusive	115	115	
AD_tier1_31 Exclusive	30	29	MS4A
Overlap	1	1