Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_female Exclusive	AD_tier1_31	1.28e-01	3.10e-01	2.35e-01	5.41e-01
AD_tier1_31 Exclusive	LBD_female	1.97e-02	5.76e-01	4.54e-01	2.65e-01
LBD_female Exclusive	AD_tier1_31 Exclusive	2.08e-01	3.76e-01	1.80e-01	6.30e-01
AD_tier1_31 Exclusive	LBD_female Exclusive	1.66e-02	6.37e-01	3.96e-01	3.21e-01
LBD_female Exclusive	Overlap	5.94e-01	1.98e-02	8.32e-01	1.19e-01
AD_tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.74e-03	1.84e-03	4.85e-38	1.04e-03



Evaluating how well LBD_female genes are linked to AD_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female Exclusive	AD_tier1_31	0.53	-1.10	-1.38	-0.86	0.51
AD_tier1_31 Exclusive	LBD_female	0.50	-0.42	-0.60	-0.35	0.03
LBD_female Exclusive	AD_tier1_31 Exclusive	0.52	-0.94	-1.34	-0.92	0.38
AD_tier1_31 Exclusive	LBD_female Exclusive	0.50	-0.63	-0.54	-0.36	-0.28
LBD_female Exclusive	Overlap	0.94	0.70	80394939534336.33	0.42	1.54
AD_tier1_31 Exclusive	Overlap	1.00	1.24	inf	1.68	1.83
Overlap	Exclusives	0.60	inf	4.22	2.58	4.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female Exclusive	AD_tier1_31	0.00	-0.82	-1.22	-0.78	-0.26
AD_tier1_31 Exclusive	LBD_female	0.01	-0.32	-0.48	-0.51	-0.33
LBD_female Exclusive	AD_tier1_31 Exclusive	0.00	-0.79	-1.16	-0.66	-0.29
AD_tier1_31 Exclusive	LBD_female Exclusive	0.01	-0.74	-0.73	-0.70	-0.61
LBD_female Exclusive	Overlap	0.00	0.04	1079443865483744.50	-0.24	0.44
AD_tier1_31 Exclusive	Overlap	0.02	29.94	151272923003761312.00	72.92	50.22
Overlap	Exclusives	0.02	2087204915984301.50	11.61	6.67	11.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_female Exclusive	111	110	AC126283.2
AD_tier1_31 Exclusive	30	29	MS4A
Overlap	1	1