Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_combined Exclusive	LBD_6	9.73e-01	4.31e-01	9.66e-01	6.24e-02
LBD_6 Exclusive	LBD_combined	1.09e-01	3.73e-01	3.31e-45	2.86e-01
LBD_combined Exclusive	LBD_6 Exclusive	7.70e-01	9.12e-01	8.62e-01	7.27e-02
LBD_6 Exclusive	LBD_combined Exclusive	1.25e-01	3.63e-01	7.79e-44	5.88e-01
LBD_combined Exclusive	Overlap	7.79e-01	5.17e-01	7.65e-01	4.31e-01
LBD_6 Exclusive	Overlap	2.96e-04	9.85e-05	9.85e-04	5.91e-04
Overlap	Exclusives	1.49e-03	1.55e-02	4.04e-49	1.36e-02



Evaluating how well LBD_combined genes are linked to LBD_6 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_combined Exclusive	LBD_6	0.81	0.09	0.88	0.22	3.04
LBD_6 Exclusive	LBD_combined	0.53	2.37	1.37	1.43	1.52
LBD_combined Exclusive	LBD_6 Exclusive	0.83	1.07	1.47	1.09	2.37
LBD_6 Exclusive	LBD_combined Exclusive	0.52	2.76	1.50	1.43	1.16
LBD_combined Exclusive	Overlap	0.78	-0.82	-1.37	-0.76	1.31
LBD_6 Exclusive	Overlap	0.99	3.34	2.43	1.96	2.25
Overlap	Exclusives	0.54	2.43	2.64	1.95	2.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_combined Exclusive	LBD_6	0.00	0.43	0.94	0.36	0.61
LBD_6 Exclusive	LBD_combined	0.01	4.03	1.11	2.12	1.80
LBD_combined Exclusive	LBD_6 Exclusive	0.00	1.42	0.10	1.52	2.24
LBD_6 Exclusive	LBD_combined Exclusive	0.01	2.31	1.02	1.28	0.69
LBD_combined Exclusive	Overlap	0.00	-0.24	0.14	-0.30	1.96
LBD_6 Exclusive	Overlap	0.01	34.76	63.68	37.46	34.73
Overlap	Exclusives	0.01	2.46	1.12	1.02	0.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_combined Exclusive	199	199	
LBD_6 Exclusive	4	4	
Overlap	2	2