Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_male Exclusive	LBD_6	6.28e-01	8.83e-01	1.95e-01	2.68e-03
LBD_6 Exclusive	LBD_male	7.97e-01	5.59e-02	2.96e-30	3.91e-05
LBD_male Exclusive	LBD_6 Exclusive	2.64e-01	9.12e-01	2.02e-01	5.36e-02
LBD_6 Exclusive	LBD_male Exclusive	7.28e-01	6.19e-02	1.88e-30	3.99e-05
LBD_male Exclusive	Overlap	9.46e-01	5.17e-01	5.37e-01	5.53e-02
LBD_6 Exclusive	Overlap	5.91e-04	9.85e-05	5.91e-04	5.91e-04
Overlap	Exclusives	3.98e-01	2.15e-01	5.49e-27	2.42e-04



Evaluating how well LBD_male genes are linked to LBD_6 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male Exclusive	LBD_6	0.80	0.40	0.38	0.69	2.50
LBD_6 Exclusive	LBD_male	0.62	1.32	2.42	1.96	4.97
LBD_male Exclusive	LBD_6 Exclusive	0.75	0.26	0.11	0.28	1.54
LBD_6 Exclusive	LBD_male Exclusive	0.61	1.16	2.57	1.83	4.10
LBD_male Exclusive	Overlap	0.91	0.59	0.48	0.97	1.88
LBD_6 Exclusive	Overlap	0.99	3.89	2.75	2.11	2.43
Overlap	Exclusives	0.62	1.42	2.40	1.63	4.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male Exclusive	LBD_6	0.01	0.79	-12.33	3.79	13.02
LBD_6 Exclusive	LBD_male	0.01	1.43	2.75	1.56	4.49
LBD_male Exclusive	LBD_6 Exclusive	0.01	2.17	-17.42	5.47	0.10
LBD_6 Exclusive	LBD_male Exclusive	0.01	0.63	1.53	1.36	2.87
LBD_male Exclusive	Overlap	0.00	-0.32	-13.60	0.33	1.15
LBD_6 Exclusive	Overlap	0.01	30.98	78.28	39.20	2.57
Overlap	Exclusives	0.01	1.68	1.45	1.88	4.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_male Exclusive	114	114	
LBD_6 Exclusive	4	4	
Overlap	2	2