Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_female Exclusive	LBD_6	4.49e-01	4.37e-01	4.68e-01	1.62e-01
LBD_6 Exclusive	LBD_female	8.41e-01	7.88e-01	6.38e-22	7.58e-01
LBD_female Exclusive	LBD_6 Exclusive	6.81e-01	6.39e-01	5.71e-01	3.01e-01
LBD_6 Exclusive	LBD_female Exclusive	7.83e-01	6.50e-01	2.70e-23	4.60e-01
LBD_female Exclusive	Overlap	8.72e-01	8.04e-01	6.77e-01	6.93e-01
LBD_6 Exclusive	Overlap	1.48e-03	9.85e-05	2.07e-03	1.48e-03
Overlap	Exclusives	7.07e-03	1.86e-01	1.49e-24	7.89e-02



Evaluating how well LBD_female genes are linked to LBD_6 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female Exclusive	LBD_6	0.60	-1.82	-2.35	-1.79	0.95
LBD_6 Exclusive	LBD_female	0.50	-0.52	-0.84	-0.88	-0.11
LBD_female Exclusive	LBD_6 Exclusive	0.55	-1.81	-1.83	-2.01	0.43
LBD_6 Exclusive	LBD_female Exclusive	0.49	-0.55	-1.24	-0.96	-0.47
LBD_female Exclusive	Overlap	0.70	-0.70	-1.09	-1.00	0.90
LBD_6 Exclusive	Overlap	0.99	3.49	3.01	2.24	2.25
Overlap	Exclusives	0.55	2.88	1.71	1.51	1.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female Exclusive	LBD_6	0.00	-0.43	-0.79	-0.54	-0.04
LBD_6 Exclusive	LBD_female	0.01	-0.32	-0.41	-0.41	-0.32
LBD_female Exclusive	LBD_6 Exclusive	0.00	-0.30	-0.66	-0.62	0.47
LBD_6 Exclusive	LBD_female Exclusive	0.01	-0.79	-0.59	-1.03	-0.58
LBD_female Exclusive	Overlap	0.00	-0.47	-0.60	-0.64	-0.05
LBD_6 Exclusive	Overlap	0.01	19.93	76.91	24.69	14.01
Overlap	Exclusives	0.01	2.04	0.45	0.29	0.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_female Exclusive	110	109	AC126283.2
LBD_6 Exclusive	4	4	
Overlap	2	2