Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) LBD_combined Exclusive Singleton 5.17e-01 1.47e-01 4.14e-01 2.83e-05 Singleton Exclusive LBD_combined 1.10e-01 4.95e-01 8.68e-09 7.73e-01 LBD_combined Exclusive Singleton Exclusive 3.93e-01 5.75e-02 3.39e-01 9.92e-06 Singleton Exclusive LBD_combined Exclusive 5.64e-02 4.38e-01 5.86e-09 7.27e-01 LBD_combined Exclusive Overlap 3.17e-01 5.15e-01 4.75e-01 7.92e-01 Singleton Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 6.06e-08 1.67e-03 2.61e-37 1.46e-04 Evaluating how well LBD_combined genes are linked to Singleton genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) LBD_combined Exclusive Singleton 0.74 0.62 1.83 0.65 4.19 Singleton Exclusive LBD_combined 0.50 0.33 -0.74 -0.50 -0.17 LBD_combined Exclusive Singleton Exclusive 0.75 0.66 2.03 0.84 3.86 Singleton Exclusive LBD_combined Exclusive 0.49 0.03 -0.84 -0.25 -0.26 LBD_combined Exclusive Overlap 0.61 -1.23 -0.96 -0.86 0.38 Singleton Exclusive Overlap 1.00 2.63 2.19 1.94 1.66 Overlap Exclusives 0.57 3.43 3.30 2.83 3.37 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) LBD_combined Exclusive Singleton 0.00 1.16 1.19 1.03 6.76 Singleton Exclusive LBD_combined 0.01 3.23 1.82 2.20 2.42 LBD_combined Exclusive Singleton Exclusive 0.00 1.04 1.76 1.24 5.08 Singleton Exclusive LBD_combined Exclusive 0.01 0.90 1.07 1.22 0.59 LBD_combined Exclusive Overlap 0.00 -0.44 -0.78 -0.52 -0.20 Singleton Exclusive Overlap 0.06 689.99 390.17 188.84 119.52 Overlap Exclusives 0.02 6.54 3.68 3.70 4.07 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes LBD_combined Exclusive 200 200 Singleton Exclusive 20 20 Overlap 1 1