Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_male Exclusive	Singleton	9.70e-01	2.55e-01	1.03e-01	2.39e-03
Singleton Exclusive	LBD_male	9.60e-04	2.90e-01	9.55e-08	2.78e-02
LBD_male Exclusive	Singleton Exclusive	9.34e-01	2.81e-01	2.98e-01	8.41e-03
Singleton Exclusive	LBD_male Exclusive	9.24e-04	2.11e-01	3.83e-08	2.27e-02
LBD_male Exclusive	Overlap	9.11e-01	7.13e-01	2.77e-01	1.58e-01
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.33e-04	1.27e-03	5.12e-25	2.73e-07



Evaluating how well LBD_male genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male Exclusive	Singleton	0.72	0.07	1.33	0.68	3.27
Singleton Exclusive	LBD_male	0.56	-0.96	-0.71	-0.39	2.07
LBD_male Exclusive	Singleton Exclusive	0.71	0.00	1.28	0.29	3.60
Singleton Exclusive	LBD_male Exclusive	0.55	-0.88	-0.81	-0.38	1.87
LBD_male Exclusive	Overlap	0.87	0.39	0.74	0.95	1.43
Singleton Exclusive	Overlap	1.00	2.19	1.97	2.10	1.64
Overlap	Exclusives	0.65	3.61	4.59	2.43	6.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male Exclusive	Singleton	0.00	-0.04	-3.13	0.97	1.34
Singleton Exclusive	LBD_male	0.01	2.60	1.22	1.71	2.85
LBD_male Exclusive	Singleton Exclusive	0.00	-0.09	-3.11	0.39	3.26
Singleton Exclusive	LBD_male Exclusive	0.01	0.73	0.01	0.39	1.79
LBD_male Exclusive	Overlap	0.00	-0.23	0.43	0.10	-0.07
Singleton Exclusive	Overlap	0.06	394.88	241.87	420.74	62.24
Overlap	Exclusives	0.02	11.08	10.19	5.26	12.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_male Exclusive	115	115	
Singleton Exclusive	20	20	
Overlap	1	1