Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_female Exclusive	Singleton	3.08e-01	6.59e-01	3.08e-01	1.28e-01
Singleton Exclusive	LBD_female	1.81e-02	5.60e-02	2.53e-06	1.09e-01
LBD_female Exclusive	Singleton Exclusive	4.21e-01	8.63e-01	4.85e-01	1.81e-01
Singleton Exclusive	LBD_female Exclusive	8.51e-03	3.90e-02	5.36e-06	4.55e-02
LBD_female Exclusive	Overlap	2.97e-01	5.35e-01	3.96e-01	9.90e-01
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.39e-05	1.37e-02	1.38e-21	2.14e-04



Evaluating how well LBD_female genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female Exclusive	Singleton	0.62	-1.18	-1.33	-1.30	1.72
Singleton Exclusive	LBD_female	0.48	-0.75	-1.69	-1.36	-0.70
LBD_female Exclusive	Singleton Exclusive	0.62	-1.11	-0.93	-1.07	1.96
Singleton Exclusive	LBD_female Exclusive	0.47	-0.80	-1.98	-1.27	-0.92
LBD_female Exclusive	Overlap	0.52	-1.29	-1.11	-0.93	0.01
Singleton Exclusive	Overlap	1.00	2.83	1.80	1.84	2.08
Overlap	Exclusives	0.61	3.99	3.22	3.49	4.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female Exclusive	Singleton	0.00	-0.97	-1.28	-1.09	0.62
Singleton Exclusive	LBD_female	0.01	0.66	-0.16	0.04	0.25
LBD_female Exclusive	Singleton Exclusive	0.00	-0.91	-0.98	-0.88	0.50
Singleton Exclusive	LBD_female Exclusive	0.01	-0.73	-1.10	-0.57	-0.65
LBD_female Exclusive	Overlap	0.00	-0.12	-0.73	-0.50	-0.30
Singleton Exclusive	Overlap	0.06	505.31	234.27	121.15	328.71
Overlap	Exclusives	0.01	8.84	6.15	2.97	4.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_female Exclusive	111	110	AC126283.2
Singleton Exclusive	20	20	
Overlap	1	1