Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_combined Exclusive	Meta_GS	3.19e-01	3.08e-01	5.39e-01	3.95e-03
Meta_GS Exclusive	PD_combined	8.06e-01	7.39e-01	9.55e-03	7.43e-01
PD_combined Exclusive	Meta_GS Exclusive	6.79e-01	2.99e-01	6.86e-01	5.45e-03
Meta_GS Exclusive	PD_combined Exclusive	7.61e-01	8.33e-01	2.71e-02	8.80e-01
PD_combined Exclusive	Overlap	2.18e-01	1.52e-01	1.92e-01	3.11e-01
Meta_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-04	2.96e-04
Overlap	Exclusives	1.07e-05	2.56e-02	2.68e-01	9.67e-04



Evaluating how well PD_combined genes are linked to Meta_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined Exclusive	Meta_GS	0.61	1.21	1.45	1.20	3.60
Meta_GS Exclusive	PD_combined	0.52	1.40	1.50	1.85	1.06
PD_combined Exclusive	Meta_GS Exclusive	0.60	1.12	1.25	1.05	3.30
Meta_GS Exclusive	PD_combined Exclusive	0.51	1.43	0.98	1.04	0.64
PD_combined Exclusive	Overlap	0.78	1.89	1.89	2.02	1.36
Meta_GS Exclusive	Overlap	0.99	3.20	3.28	2.98	2.34
Overlap	Exclusives	0.57	2.96	3.54	3.51	4.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined Exclusive	Meta_GS	0.01	1.43	2.16	0.88	4.16
Meta_GS Exclusive	PD_combined	0.01	1.41	2.82	1.43	1.29
PD_combined Exclusive	Meta_GS Exclusive	0.01	2.02	2.30	1.80	1.12
Meta_GS Exclusive	PD_combined Exclusive	0.01	1.46	1.41	0.57	0.42
PD_combined Exclusive	Overlap	0.00	0.24	0.33	0.39	-0.10
Meta_GS Exclusive	Overlap	0.01	65.59	99.78	7.03	40.50
Overlap	Exclusives	0.02	6.94	5.60	6.27	7.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_combined Exclusive	166	165	AP000781.2
Meta_GS Exclusive	82	80	TTC6;RP11-297N6.4
Overlap	2	2