Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_female Exclusive	Meta_GS	6.57e-01	7.87e-01	2.28e-01	7.15e-02
Meta_GS Exclusive	PD_female	7.06e-01	3.14e-01	3.09e-02	1.77e-01
PD_female Exclusive	Meta_GS Exclusive	6.00e-01	7.33e-01	2.76e-01	5.47e-02
Meta_GS Exclusive	PD_female Exclusive	9.74e-01	5.86e-01	7.39e-02	2.70e-01
PD_female Exclusive	Overlap	3.69e-01	4.12e-01	3.04e-01	6.61e-01
Meta_GS Exclusive	Overlap	9.85e-05	9.85e-05	5.91e-04	5.91e-04
Overlap	Exclusives	1.58e-03	2.55e-02	2.20e-01	7.18e-04



Evaluating how well PD_female genes are linked to Meta_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female Exclusive	Meta_GS	0.58	0.31	0.53	0.54	2.48
Meta_GS Exclusive	PD_female	0.56	1.22	1.53	0.99	2.41
PD_female Exclusive	Meta_GS Exclusive	0.58	0.32	0.40	0.31	2.46
Meta_GS Exclusive	PD_female Exclusive	0.55	0.60	0.71	0.75	2.02
PD_female Exclusive	Overlap	0.63	0.87	0.78	1.08	0.52
Meta_GS Exclusive	Overlap	0.99	3.34	3.30	3.41	2.50
Overlap	Exclusives	0.60	2.13	2.76	2.02	4.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female Exclusive	Meta_GS	0.01	0.42	0.04	0.70	2.21
Meta_GS Exclusive	PD_female	0.01	1.41	1.91	1.25	0.59
PD_female Exclusive	Meta_GS Exclusive	0.01	0.49	-0.02	0.58	2.13
Meta_GS Exclusive	PD_female Exclusive	0.01	0.07	0.45	0.33	0.23
PD_female Exclusive	Overlap	0.00	-0.15	-0.25	-0.20	-0.26
Meta_GS Exclusive	Overlap	0.01	89.44	106.19	16.06	0.68
Overlap	Exclusives	0.02	5.67	6.21	6.05	7.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_female Exclusive	90	90	
Meta_GS Exclusive	82	80	TTC6;RP11-297N6.4
Overlap	2	2