Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PDD	GS_tier1	1.73e-02	1.40e-02	3.87e-02	4.47e-01
GS_tier1	PDD	2.86e-04	1.18e-01	1.15e-01	3.06e-01



Evaluating how well PDD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD	GS_tier1	0.51	-1.27	-2.14	-1.11	0.40
GS_tier1	PDD	0.50	-1.77	-0.78	-0.81	-0.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD	GS_tier1	0.00	-0.87	-1.11	-0.63	-0.17
GS_tier1	PDD	0.00	-1.28	-0.96	-0.85	-0.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PDD	53	53	
GS_tier1	31	30	MS4A