Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PDD Exclusive	LBD_GS	6.21e-01	5.42e-01	9.49e-01	1.01e-01
LBD_GS Exclusive	PDD	4.09e-01	8.77e-01	4.70e-14	2.98e-01
PDD Exclusive	LBD_GS Exclusive	8.18e-01	5.01e-01	8.68e-01	3.17e-02
LBD_GS Exclusive	PDD Exclusive	4.15e-01	8.62e-01	4.71e-13	4.74e-01
PDD Exclusive	Overlap	6.73e-01	4.55e-01	9.50e-01	8.12e-01
LBD_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.77e-03	2.00e-01	4.31e-12	6.94e-03



Evaluating how well PDD genes are linked to LBD_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD Exclusive	LBD_GS	0.68	-0.90	-0.89	-0.44	1.35
LBD_GS Exclusive	PDD	0.54	-5.03	0.20	0.14	1.44
PDD Exclusive	LBD_GS Exclusive	0.69	-0.74	-1.37	-0.27	1.53
LBD_GS Exclusive	PDD Exclusive	0.53	-4.97	0.14	0.03	1.02
PDD Exclusive	Overlap	0.65	-0.38	0.15	-0.10	0.48
LBD_GS Exclusive	Overlap	1.00	3.65	1.93	1.85	1.51
Overlap	Exclusives	0.62	2.07	2.96	2.20	3.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD Exclusive	LBD_GS	0.00	-1.26	-2.11	-0.50	0.30
LBD_GS Exclusive	PDD	0.00	-1.01	0.16	0.12	1.58
PDD Exclusive	LBD_GS Exclusive	0.00	-0.68	-5.06	-0.46	0.54
LBD_GS Exclusive	PDD Exclusive	0.00	-2.29	-0.49	-0.56	-0.07
PDD Exclusive	Overlap	0.00	-0.54	-0.37	-0.28	-0.20
LBD_GS Exclusive	Overlap	0.02	18.15	155.94	32.94	60.27
Overlap	Exclusives	0.01	2.72	1.81	2.87	3.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PDD Exclusive	52	52	
LBD_GS Exclusive	5	5	
Overlap	1	1