Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB_PDD Exclusive	LBD_combined	7.52e-01	9.63e-01	6.28e-01	9.55e-01
LBD_combined Exclusive	UKB_PDD	4.68e-01	3.52e-01	2.78e-01	7.03e-02
UKB_PDD Exclusive	LBD_combined Exclusive	8.72e-01	9.46e-01	5.85e-01	9.82e-01
LBD_combined Exclusive	UKB_PDD Exclusive	5.12e-01	3.93e-01	4.04e-01	1.89e-01
UKB_PDD Exclusive	Overlap	7.92e-01	9.96e-01	8.51e-01	6.61e-01
LBD_combined Exclusive	Overlap	9.25e-01	8.17e-01	8.29e-01	3.60e-01
Overlap	Exclusives	2.21e-07	2.04e-03	3.29e-21	2.10e-03



Evaluating how well UKB_PDD genes are linked to LBD_combined genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PDD Exclusive	LBD_combined	0.50	0.18	0.10	-0.15	0.10
LBD_combined Exclusive	UKB_PDD	0.56	0.09	0.83	0.55	1.63
UKB_PDD Exclusive	LBD_combined Exclusive	0.50	0.17	0.02	-0.12	0.23
LBD_combined Exclusive	UKB_PDD Exclusive	0.55	0.17	0.65	0.28	1.10
UKB_PDD Exclusive	Overlap	0.56	0.12	0.01	-0.32	0.29
LBD_combined Exclusive	Overlap	0.74	0.39	0.79	0.58	0.91
Overlap	Exclusives	0.56	3.14	3.38	2.63	2.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PDD Exclusive	LBD_combined	0.01	-0.01	-0.15	-0.28	-0.19
LBD_combined Exclusive	UKB_PDD	0.00	-0.52	0.08	-0.18	0.34
UKB_PDD Exclusive	LBD_combined Exclusive	0.01	-0.08	-0.22	-0.29	-0.12
LBD_combined Exclusive	UKB_PDD Exclusive	0.00	-0.39	-0.05	-0.35	0.12
UKB_PDD Exclusive	Overlap	0.00	-0.44	-0.38	-0.30	-0.22
LBD_combined Exclusive	Overlap	0.00	-0.31	-0.04	-0.28	-0.15
Overlap	Exclusives	0.01	1.94	1.71	1.26	1.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB_PDD Exclusive	51	51	
LBD_combined Exclusive	199	199	
Overlap	2	2