Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined_LBD Exclusive	Tau supp_18	2.08e-01	3.52e-01	4.27e-01	3.77e-03
Tau supp_18 Exclusive	Combined_LBD	7.61e-01	2.99e-01	6.41e-09	2.91e-01
Combined_LBD Exclusive	Tau supp_18 Exclusive	3.58e-01	6.81e-01	6.81e-01	1.59e-02
Tau supp_18 Exclusive	Combined_LBD Exclusive	6.61e-01	2.74e-01	1.28e-08	3.70e-01
Combined_LBD Exclusive	Overlap	2.77e-01	1.98e-02	3.17e-01	1.39e-01
Tau supp_18 Exclusive	Overlap	5.35e-01	9.70e-01	7.72e-01	7.13e-01
Overlap	Exclusives	1.41e-05	5.46e-02	2.56e-30	7.79e-03



Evaluating how well Combined_LBD genes are linked to Tau supp_18 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_LBD Exclusive	Tau supp_18	0.71	1.31	1.23	1.05	3.11
Tau supp_18 Exclusive	Combined_LBD	0.52	1.25	1.13	1.03	0.89
Combined_LBD Exclusive	Tau supp_18 Exclusive	0.70	0.83	0.67	0.62	2.88
Tau supp_18 Exclusive	Combined_LBD Exclusive	0.52	1.26	1.24	0.97	0.88
Combined_LBD Exclusive	Overlap	0.93	1.03	1.49	1.19	1.49
Tau supp_18 Exclusive	Overlap	0.63	-0.71	-0.20	-0.69	0.63
Overlap	Exclusives	0.53	0.97	1.13	0.88	1.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_LBD Exclusive	Tau supp_18	0.00	0.96	0.82	0.64	0.48
Tau supp_18 Exclusive	Combined_LBD	0.01	0.84	1.00	0.31	0.28
Combined_LBD Exclusive	Tau supp_18 Exclusive	0.00	0.32	0.27	-0.01	-0.02
Tau supp_18 Exclusive	Combined_LBD Exclusive	0.01	0.57	0.76	0.44	0.40
Combined_LBD Exclusive	Overlap	0.00	0.40	2.96	0.48	0.47
Tau supp_18 Exclusive	Overlap	0.00	-0.39	-0.47	-0.44	-0.14
Overlap	Exclusives	0.01	1.37	0.82	0.73	0.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined_LBD Exclusive	200	200	
Tau supp_18 Exclusive	17	17	
Overlap	1	1