Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_male	Tau_Supp	2.82e-02	3.77e-02	1.90e-02	7.81e-04
Tau_Supp	LBD_male	2.17e-02	6.33e-03	8.40e-06	7.31e-04



Evaluating how well LBD_male genes are linked to Tau_Supp genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male	Tau_Supp	0.75	1.92	1.98	1.36	3.62
Tau_Supp	LBD_male	0.60	2.65	2.00	1.37	3.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_male	Tau_Supp	0.00	2.53	5.78	1.98	2.56
Tau_Supp	LBD_male	0.01	2.82	0.68	1.94	2.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_male	116	116	
Tau_Supp	18	18