Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_female	Tau_supp	3.23e-01	2.34e-01	3.43e-01	1.60e-01
Tau_supp	LBD_female	6.33e-01	7.59e-01	5.53e-03	7.08e-01



Evaluating how well LBD_female genes are linked to Tau_supp genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female	Tau_supp	0.59	-0.85	-1.26	-0.96	1.30
Tau_supp	LBD_female	0.50	-0.25	-0.64	-0.33	0.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_female	Tau_supp	0.00	-0.47	-0.70	-0.50	0.73
Tau_supp	LBD_female	0.01	-0.40	-0.75	-0.72	-0.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_female	112	111	AC126283.2
Tau_supp	18	18