Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PDD	Tau_Supp	1.02e-01	9.22e-02	1.29e-01	8.89e-02
Tau_Supp	PDD	4.25e-01	8.26e-01	1.05e-02	5.13e-01



Evaluating how well PDD genes are linked to Tau_Supp genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD	Tau_Supp	0.58	-0.86	-1.63	-1.23	1.13
Tau_Supp	PDD	0.53	-0.48	0.43	0.03	0.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PDD	Tau_Supp	0.00	-0.80	-1.52	-0.96	-0.15
Tau_Supp	PDD	0.00	-0.39	-0.50	-0.66	-0.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PDD	53	53	
Tau_Supp	18	18