Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_combined	Tau_supp	4.27e-01	5.48e-01	5.80e-01	8.63e-04
Tau_supp	PD_combined	3.24e-01	5.45e-01	2.88e-04	2.78e-01



Evaluating how well PD_combined genes are linked to Tau_supp genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined	Tau_supp	0.69	1.01	1.16	0.68	3.20
Tau_supp	PD_combined	0.50	0.42	0.16	0.50	-0.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_combined	Tau_supp	0.00	0.46	0.32	0.03	0.55
Tau_supp	PD_combined	0.01	0.04	0.11	-0.05	-0.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_combined	168	167	AP000781.2
Tau_supp	18	18