Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_female	Tau_supp	8.37e-02	2.12e-01	2.06e-01	1.64e-01
Tau_supp	PD_female	8.70e-01	7.69e-01	1.55e-02	2.96e-01



Evaluating how well PD_female genes are linked to Tau_supp genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Tau_supp	0.56	-1.91	-1.13	-1.62	0.81
Tau_supp	PD_female	0.52	-0.16	-0.91	-1.03	0.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_female	Tau_supp	0.00	-1.32	-0.92	-0.79	-0.14
Tau_supp	PD_female	0.00	-0.33	-0.51	-1.10	-0.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_female	92	92	
Tau_supp	18	18