Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) APOE3_AD_WESr2_randomly_selection_z35 Exclusive tier1_31 2.87e-01 3.72e-01 3.77e-01 1.89e-02 tier1_31 Exclusive APOE3_AD_WESr2_randomly_selection_z35 7.98e-01 9.77e-02 1.34e-01 5.94e-02 APOE3_AD_WESr2_randomly_selection_z35 Exclusive tier1_31 Exclusive 3.26e-01 7.26e-01 3.56e-01 1.95e-02 tier1_31 Exclusive APOE3_AD_WESr2_randomly_selection_z35 Exclusive 7.67e-01 2.74e-01 8.28e-02 1.24e-01 APOE3_AD_WESr2_randomly_selection_z35 Exclusive Overlap 2.57e-01 4.16e-01 6.93e-01 5.35e-01 tier1_31 Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 3.12e-08 9.84e-08 6.74e-09 1.10e-08 Evaluating how well APOE3_AD_WESr2_randomly_selection_z35 genes are linked to tier1_31 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) APOE3_AD_WESr2_randomly_selection_z35 Exclusive tier1_31 0.63 0.97 0.95 0.47 2.62 tier1_31 Exclusive APOE3_AD_WESr2_randomly_selection_z35 0.57 0.90 1.59 1.23 1.72 APOE3_AD_WESr2_randomly_selection_z35 Exclusive tier1_31 Exclusive 0.63 1.15 0.68 0.60 2.15 tier1_31 Exclusive APOE3_AD_WESr2_randomly_selection_z35 Exclusive 0.56 0.93 1.03 1.69 1.53 APOE3_AD_WESr2_randomly_selection_z35 Exclusive Overlap 0.74 1.23 0.88 0.59 0.80 tier1_31 Exclusive Overlap 1.00 1.68 2.00 1.91 1.62 Overlap Exclusives 0.68 2.27 5.30 2.63 5.07 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) APOE3_AD_WESr2_randomly_selection_z35 Exclusive tier1_31 0.00 0.17 -0.25 -0.17 0.81 tier1_31 Exclusive APOE3_AD_WESr2_randomly_selection_z35 0.00 1.66 2.45 0.60 2.36 APOE3_AD_WESr2_randomly_selection_z35 Exclusive tier1_31 Exclusive 0.00 0.38 -0.35 -0.06 0.37 tier1_31 Exclusive APOE3_AD_WESr2_randomly_selection_z35 Exclusive 0.00 0.14 0.50 0.45 0.49 APOE3_AD_WESr2_randomly_selection_z35 Exclusive Overlap 0.00 0.26 -0.10 -0.21 -0.12 tier1_31 Exclusive Overlap 0.06 55.87 403.25 77.54 14.26 Overlap Exclusives 0.04 9.12 44.82 20.95 47.52 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes APOE3_AD_WESr2_randomly_selection_z35 Exclusive 67 65 AC093155.3;RFPL2 tier1_31 Exclusive 30 29 MS4A Overlap 1 1