Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AllEaml	GS	2.22e-02	6.62e-02	7.38e-01	1.46e-10
GS	AllEaml	2.91e-01	2.50e-01	3.63e-04	8.21e-01



Evaluating how well AllEaml genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AllEaml	GS	0.66	1.48	3.02	0.76	6.68
GS	AllEaml	0.50	3.31	1.85	1.28	0.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AllEaml	GS	0.02	1.61	4.84	0.55	7.73
GS	AllEaml	0.01	3.69	0.61	0.33	0.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AllEaml	131	131	
GS	203	180	RTELI;SnoU13;COLCA1;ZMIZ1-AS1;LINC00917;TERC;SAT2B-AS1;LOC146513;METRLN;ANRIL;c11orf53;CDKN2B-AS1;POUF5F1B;SCL22A3; MYNN;LINC00673;SNHG15; PIGU;LINC00603;HLA class I;LINC00675;7-Mar;HLA class II